Adult Hepatology Department – Hôpital Paul Brousse

12 Avenue Paul Vaillant Couturier 94800 Villejuif

Head: Dr Rodolphe SOBESKY
Secretariat: Claire PILLEVESSE
Telephone: 01 45 59 34 33
Fax: 01 45 59 38 57


  • Hepatologists: Dr Rodolphe SOBESKY, Pr Jean-Charles DUCLOS-VALLEE
  • Nurse – Clinical Research Associate: Mathilde GAILLOT
hopital paul brousse

Patients with Wilson’s disease can be managed at the Paul Brousse site through either:

  1. Standard consultations
  2. Hospitalisation in the Day Hospital where a variety of supplementary investigations can be carried out, such as abdominal ultrasound, upper gastrointestinal endoscopy under anaesthetic and the determination of hepatic fibrosis using a Fibroscan. Consultations may also be carried out during this short period of hospitalisation
  3. Standard hospitalisation in the event of a decompensation of liver disease.

Molecular biology investigations are carried out by the Molecular Genetics Department.
Copper assessments are performed by the Toxicology Department at Hôpital Lariboisière.

Logo Paul Brousse

Paediatric Hepatology Department, Hôpital Bicêtre

78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre

Head: Pr Emmanuel JACQUEMIN
Secretariat: Isabelle FRITEAU
Telephone: 01 45 21 37 90
Fax: 01 45 21 28 16


  • Paediatric Hepatologists: Pr Emmanuel JACQUEMIN, Dr Dalila HABES
  • Molecular biologists: Micheline MISRAHI, Anne MANTEL
  • Clinical psychologists: Maya ASSAYAH, Alexandra FLOURIS
  • Dietician: Joëlle WENZ
hopital bicetre

Children with Wilson’s disease can be managed at the Bicêtre site through:

  1. Consultations at the Paediatric Polyclinic where they can see doctors from the Paediatric Hepatology Department, and dieticians and nurses from the centre.
  2. Hospitalisation in the Paediatric Hepatology Department or Paediatric Intensive Care Unit if they suffer from the most severe forms of the disease (fulminant Wilson’s disease)

Molecular biology investigations are carried out by the Molecular Genetics Department.

Copper assessments are performed by the Toxicology Department at Hôpital Lariboisière.

Paediatric Gastroenterology, Hepatology and Nutrition Department
Hôpital Femme-Mère-Enfant, LYON University Hospitals

59 Boulevard Pinel 69677 Bron

Head: Pr Alain LACHAUX
Coordinating physician at the CNR Wilson Lyon: Dr Anne-Sophie BRUNET
Secretariat: Victoria PATISSIER
Telephone: 04 27 85 59 81
Fax: 04 27 85 67 56


  • Care managers: Martine MARTIN, Magalie VEST-MICHALET
  • Paediatric hepatologists: Alain LACHAUX, Anne-Sophie BRUNET
  • Adult hepatologists: Olivier GUILLAUD, Jérôme DUMORTIER
  • Adult neurologists: Emmanuel BROUSSOLLE, Chloé LAURENCIN, Stéphane THOBOIS
  • Paediatric neurologist: Laurence LION-FRANCOIS
  • Research officer – Clinical Research Associate: Abdelouahed BELMALIH
  • Geneticist: Linda PONS
  • Psychiatrist: Caroline DEMILY
  • Psychologist specialized in neuropsychology: Emilie DECRETTE

hopital bron

Patients with Wilson’s disease can be managed at the Lyon sites through:

1. Standard consultations in specialist departments

  • Paediatric hepatology: Hôpital Femme Mère Enfant
  • Paediatric Neurology: Hôpital Femme Mère Enfant
  • Adult hepatology: Hôpital Edouard Herriot
  • Adult neurology: Hôpital Pierre Wertheimer

2. Multidisciplinary consultations

The following may be involved:

  • Paediatric hepatologist: Pr Alain LACHAUX or Dr Anne-Sophie BRUNET
  • Hepatologist: Dr Olivier GUILLAUD or Pr Jérôme DUMORTIER
  • Neurologist: Pr Emmanuel BROUSSOLLE or Dr Chloé LAURENCIN or Pr Stéphane THOBOIS
  • Paediatric neurologist: Dr Laurence LION-FRANCOIS
  • Geneticist: Dr Linda PONS
  • Biologist: Dr Muriel BOST
  • Psychologist specialized in neuropsychology: Emilie DECRETTE
  • Research officer – Clinical Research Associate: Abdelouahed BELMALIH

If necessary, the following may be asked to attend, or an appointment can be made with:

  • Psychiatrist: Dr Caroline DEMILY
  • Dietician: Manolita LOPEZ
  • A social worker from the department where the patient is hospitalised
  • A dermatologist from the paediatric or adult medicine departments
  • An ophthalmologist at Hôpital Edouard Herriot or Hôpital Pierre Wertheimer

3. Hospitalisation in the Day Hospital or an inpatient ward:
where the same specialists and doctors responsible for the management and follow-up of liver transplant patients will be involved.

For children: Pr Lachaux – Dr Brunet – Dr Le Gall – Dr Rivet – Dr Heissat.
For adults : the « adult » team for Lyon, which includes Professor Dumortier – Dr Guillaud.

Molecular biology investigations are carried out by Dr Muriel BOST at :

The East Lyon Centre for Biology and Pathology – Molecular Neurogenetics and the Network of Hereditary Metabolic Diseases.

Copper assessments, including that of exchangeable copper (Cu EXE) and the ratio of exchangeable copper/total copper (REC), are performed by Dr Muriel BOST in the Laboratory for Trace Metal Analysis (Biochemistry Department) at Hôpital Edouard Herriot, Lyon.

Following a neuropsychological assessment, patients may be seen by Dr Caroline DEMILY (psychiatrist) for a review of their case and appropriate cognitive/psychiatric management:

Regional Centre for the Screening and Management of Psychiatric Disorders of Genetic Origin
Centre Hospitalier le Vinatier
95, boulevard Pinel 69500 Bron
Pôle Est – Bâtiment 505 – Unité CRESOP

Patients who suffer from dystonia may benefit from treatment with botulinum toxin, which is administered in the department headed by Dr Christophe VIAL at Hôpital Neurologique Pierre Wertheimer in Lyon.